Iclusig 15 mg film-coated tablets. Each tablet contains 15 mg of ponatinib (equivalent to 16.03 mg ponatinib HCl). The box indicates it contains 30 tablets and is for \"Rx only,\" meaning it requires a prescription. Iclusig (ponatinib) is a highly specialized targeted therapy medication used in the treatment of specific types of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) that are resistant to other treatments. It is distributed by Takeda Pharmaceuticals. This powerful medication must be used under the strict guidance and supervision of a qualified oncologist.